GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs9902453 | 1 | rs59274738 | chr17:28437635 | LRRC37B2 | chr17:28903483-28992715:+ | 0.17 | 3.73 | 0.000215 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs59274738 | chr17:28437635 | SSH2 | chr17:27952965-28257018:- | 0.35 | 8.15 | 3.32E-15 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs59274738 | chr17:28437635 | TP53I13 | chr17:27895739-27900174:+ | 0.19 | 5.28 | 1.94E-7 | Coffee consumption (cups per day) |
| THCA | cis | rs2129782 | 1 | rs59290812 | chr8:89441796 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.29 | 1.91E-7 | Electrodermal activity |
| THCA | cis | rs607541 | 1 | rs593126 | chr15:45935777 | SPATA5L1 | chr15:45694519-45713614:+ | 0.31 | 4.98 | 9.04E-7 | Obesity-related traits |
| THCA | cis | rs515910 | 1 | rs593151 | chr10:105935979 | C10orf79 | chr10:105889647-105992120:- | 0.25 | 8 | 9.29E-15 | Attention deficit hyperactivity disorder |
| THCA | cis | rs7679 | 1 | rs59329875 | chr20:44547672 | WFDC3 | chr20:44402847-44420547:- | -0.27 | -3.85 | 0.000132 | HDL cholesterol;Triglycerides;Gut microbiota (functional units) |
| THCA | cis | rs11574514 | 1 | rs59343240 | chr16:67850529 | C16orf86 | chr16:67700717-67702659:+ | -0.28 | -3.41 | 0.000704 | Crohn's disease |
| THCA | cis | rs11574514 | 1 | rs59343240 | chr16:67850529 | ZDHHC1 | chr16:67428323-67450339:- | 0.42 | 4.73 | 3.03E-6 | Crohn's disease |
| THCA | cis | rs7116495 | 1 | rs59343384 | chr11:71828038 | FAM86C | chr11:71498557-71512276:+ | -0.31 | -3.95 | 8.86E-5 | Severe influenza A (H1N1) infection |
| THCA | cis | rs72627123 | 1 | rs59363432 | chr14:74397545 | LIN52 | chr14:74551656-74667117:+ | 0.24 | 4.51 | 8.26E-6 | Morning vs. evening chronotype |
| THCA | cis | rs72627123 | 1 | rs59363432 | chr14:74397545 | PTGR2 | chr14:74318534-74352166:+ | 0.22 | 3.55 | 0.000429 | Morning vs. evening chronotype |
| THCA | cis | rs72627123 | 1 | rs59363432 | chr14:74397545 | ZNF410 | chr14:74318674-74398803:+ | 0.24 | 4.02 | 6.81E-5 | Morning vs. evening chronotype |
| THCA | cis | rs10095849 | 1 | rs59370060 | chr8:39398365 | ADAM32 | chr8:38965050-39142435:+ | 0.24 | 3.37 | 0.00081 | Visceral adipose tissue/subcutaneous adipose tissue ratio |
| THCA | cis | rs59374417 | 1 | rs59374417 | chr3:119288414 | ADPRH | chr3:119298523-119308791:+ | -0.21 | -3.47 | 0.000565 | Vitiligo |